Comparison of the surprising metal-ion-binding properties of 5- and 6-uracilmethylphosphonate (5Umpa2- and 6Umpa2-) in aqueous solution and crystal structures of the dimethyl and di(isopropyl) esters of H2(6Umpa).

@article{Freisinger2008ComparisonOT,
  title={Comparison of the surprising metal-ion-binding properties of 5- and 6-uracilmethylphosphonate (5Umpa2- and 6Umpa2-) in aqueous solution and crystal structures of the dimethyl and di(isopropyl) esters of H2(6Umpa).},
  author={Eva Freisinger and R o l f Griesser and Bernhard Lippert and Crist{\'o}bal F Moreno-Luque and Juan Nicl{\'o}s-Gut{\'i}errez and Justyn Ochocki and Bert P. Operschall and Helmut Sigel},
  journal={Chemistry},
  year={2008},
  volume={14 32},
  pages={10036-46}
}
5- and 6-Uracilmethylphosphonate (5Umpa(2-) and 6Umpa(2-)) as acyclic nucleotide analogues are in the focus of anticancer and antiviral research. Connected metabolic reactions involve metal ions; therefore, we determined the stability constants of M(Umpa) complexes (M(2+)=Mg(2+), Ca(2+), Mn(2+), Co(2+), Cu(2+), Zn(2+), or Cd(2+)). However, the coordination… CONTINUE READING