Comparison of the steady-state pharmacokinetics of topiramate and valproate in patients with epilepsy during monotherapy and concomitant therapy.

@article{Rosenfeld1997ComparisonOT,
  title={Comparison of the steady-state pharmacokinetics of topiramate and valproate in patients with epilepsy during monotherapy and concomitant therapy.},
  author={William E Rosenfeld and Shuang Liao and Lynn D. Kramer and Gunilla Anderson and Melissa Palmer and Ren{\'e} H. Levy and Ramchandra K. Nayak},
  journal={Epilepsia},
  year={1997},
  volume={38 3},
  pages={324-33}
}
PURPOSE The steady-state pharmacokinetics of valproate (VPA) and topiramate (TPM) were compared during VPA monotherapy, concomitant VPA and TPM therapy, and TPM monotherapy to evaluate pharmacokinetic interactions. METHODS After a 3-week baseline period, 12 patients receiving VPA monotherapy (500 to 2,250 mg every 12 h) received TPM at three escalating doses (from 100 to 200 to 400 mg every 12 h), each for 2 weeks. Thereafter, the VPA dose was tapered by 25% weekly. Blood and urine samples… CONTINUE READING

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