Comparison of the significance of CD4+ and CD8+ T lymphocytes in the protection of mice against Encephalitozoon cuniculi infection.

@article{Braunfuchsov2002ComparisonOT,
  title={Comparison of the significance of CD4+ and CD8+ T lymphocytes in the protection of mice against Encephalitozoon cuniculi infection.},
  author={Pavl{\'i}na Braunfuchsov{\'a} and J{\'i}ř{\'i} Sal{\'a}t and Jan Kopecky},
  journal={The Journal of parasitology},
  year={2002},
  volume={88 4},
  pages={
          797-9
        }
}
The role of T lymphocyte subpopulations in the protection against intraperitoneal (i.p.) and peroral Encephalitozoon cuniculi infections was compared in adoptive-transfer experiments using severe combined immunodeficient mice. Whereas CD8+ T cell-depleted, but not CD4+ T cell-depleted, BALB/c splenocytes failed to protect the mice against i.p. infection, only SCID mice reconstituted with both CD4+ T lymphocyte- and CD8+ T lymphocyte-depleted splenocytes succumbed to peroral infection. The… CONTINUE READING
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