Comparison of the side-dependent effects of Na and K on orthophosphate- , UTP-, and ATP-promoted ouabain binding to reconstituted human red blood cell ghosts

@article{Bodemann1976ComparisonOT,
  title={Comparison of the side-dependent effects of Na and K on orthophosphate- , UTP-, and ATP-promoted ouabain binding to reconstituted human red blood cell ghosts},
  author={H. H. Bodemann and Joseph F. Hoffman},
  journal={The Journal of General Physiology},
  year={1976},
  volume={67},
  pages={527 - 545}
}
This paper is concerned with analyzing the sidedness of action of various determinants which alter the rate of ouabain binding to human red blood cell ghosts. Thus, ouabain binding promoted by orthophosphate (Pi) and its inhibition by Na are shown to be due to inside Pi and inside Na. External K inhibits Pi-promoted ouabain binding and Nao acts to decrease the effectiveness of Ko. Similarly, inside uridine triphosphate (UTPi) stimulates the rate of ouabain binding which can be antagonized by… CONTINUE READING
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