Comparison of the response of primary human peripheral blood mononuclear phagocytes from different donors to challenge with model polyethylene particles of known size and dose.

Abstract

The response of primary human peripheral blood mononuclear phagocytes to challenge with polyethylene particles of known size and dose was evaluated. Particles with mean sizes of 0.21, 0.49, 4.3, 7.2, and 88 microm were co-cultured with cells for 24 h prior to the assessment of cell viability and production of the osteolytic mediators IL-1beta, IL-6… (More)

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@article{Matthews2000ComparisonOT, title={Comparison of the response of primary human peripheral blood mononuclear phagocytes from different donors to challenge with model polyethylene particles of known size and dose.}, author={J. B. Matthews and Thomas R. G. Green and Martin H. Stone and B. M. Wroblewski and J. Fisher and Elaine R. Ingham}, journal={Biomaterials}, year={2000}, volume={21 20}, pages={2033-44} }