Comparison of the prognostic potential of hyaluronic acid, hyaluronidase (HYAL-1), CD44v6 and microvessel density for prostate cancer.

@article{Ekici2004ComparisonOT,
  title={Comparison of the prognostic potential of hyaluronic acid, hyaluronidase (HYAL-1), CD44v6 and microvessel density for prostate cancer.},
  author={Sinan Ekici and Wolfgang H. Cerwinka and R Duncan and Pablo Garcia Gomez and Francisco J Civantos and Mark S. Soloway and Vinata B. Lokeshwar},
  journal={International journal of cancer},
  year={2004},
  volume={112 1},
  pages={121-9}
}
Despite the development of nomograms designed to evaluate a prostate cancer (PCa) patient's prognosis, the information has been limited to PSA, clinical stage, Gleason score and tumor volume estimates. We compared the prognostic potential of 4 histologic markers, hyaluronic acid (HA), HYAL-1-type hyaluronidase (HAase), CD44v6 and microvessel density (MVD) using immunohistochemistry. HA is a glycosaminoglycan that promotes tumor metastasis. CD44 glycoproteins serve as cell surface receptors for… CONTINUE READING