Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells.

@article{Fredholm2001ComparisonOT,
  title={Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells.},
  author={Bertil B. Fredholm and Eva Irenius and Bj{\"o}rn Kull and Gunnar Schulte},
  journal={Biochemical pharmacology},
  year={2001},
  volume={61 4},
  pages={443-8}
}
The potency of adenosine and inosine as agonists at human adenosine receptors was examined in a functional assay using changes in cyclic AMP (cAMP) formation in intact Chinese hamster ovary (CHO) cells stably transfected with the human A1, A2A, A2B, and A3 receptors. Adenosine increased cAMP formation in cells expressing the A2A (EC(50): 0.7 microM) and A2B (EC(50): 24 microM) receptors and inhibited forskolin (0.3-3 microM)-stimulated cAMP formation in cells expressing the A1 (EC(50): 0.31… CONTINUE READING
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