Comparison of the positive inotropic effects of serotonin, histamine, angiotensin II, endothelin and isoprenaline in the isolated human right atrium

@article{Zerkowski1993ComparisonOT,
  title={Comparison of the positive inotropic effects of serotonin, histamine, angiotensin II, endothelin and isoprenaline in the isolated human right atrium},
  author={H. -R. Zerkowski and Andrea Broede and Klaus Kunde and Steffen Hillemann and Ellen Schaefer and Magdalene Vogelsang and Martin C Michel and O. E. Brodde},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1993},
  volume={347},
  pages={347-352}
}
The receptor systems through which serotonin (5-HT), histamine, angiotensin II and endothelin increase the force of contraction were studied in isolated right atria from patients without apparent heart failure. All agonists increased the atrial force of contraction in a concentration-dependent manner; maximal effects, however, were significantly less than those evoked by isoprenaline or Ca2+. 5-HT and histamine, but not angiotensin II and endothelin, activated adenylate cyclase, whereas… CONTINUE READING
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