Comparison of the pharmacological profiles of cyclosporine, (Nva2)-cyclosporine and (Val2)dihydro-cyclosporine.

@article{Hiestand1985ComparisonOT,
  title={Comparison of the pharmacological profiles of cyclosporine, (Nva2)-cyclosporine and (Val2)dihydro-cyclosporine.},
  author={Peter C Hiestand and Helen Gunn and James M. Gale and Bernhard Ryffel and Jean F Borel},
  journal={Immunology},
  year={1985},
  volume={55 2},
  pages={249-55}
}
The pharmacological profiles of two new derivatives of the immunosuppressive drug, cyclosporine, is presented here. (Nva2)-CS has very similar properties to CS, but lacks the nephrotoxic side-effects. This derivative appears to be a potential successor to cyclosporine. (Val2)DH-CS seems to have a different spectrum of activities. It does not suppress… CONTINUE READING