Comparison of the pharmacokinetics of moxidectin and ivermectin after oral administration to beagle dogs.

@article{Alazzam2007ComparisonOT,
  title={Comparison of the pharmacokinetics of moxidectin and ivermectin after oral administration to beagle dogs.},
  author={Sayer I. Al-azzam and Lawrence Fleckenstein and Kuei-Ju Cheng and Michael T. Dzimianski and J Weir Mccall},
  journal={Biopharmaceutics & drug disposition},
  year={2007},
  volume={28 8},
  pages={
          431-8
        }
}
This study compares plasma disposition kinetics of ivermectin and moxidectin after oral administration to beagle dogs experimentally infected with the filarial parasite, Brugia pahangi. Sixteen dogs were selected and randomly allocated into two groups of eight dogs each. Animals in each group received either ivermectin or moxidectin by oral route at a dose of 250 microg/kg. Blood samples were collected from 0.5 h up to 56 days post-treatment and the plasma was analysed by high performance… CONTINUE READING
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