Comparison of the pharmacokinetics of diazepam after single and subchronic doses

@article{Klotz2004ComparisonOT,
  title={Comparison of the pharmacokinetics of diazepam after single and subchronic doses},
  author={Ulrich Klotz and K. H. Antonin and Peter R. Bieck},
  journal={European Journal of Clinical Pharmacology},
  year={2004},
  volume={10},
  pages={121-126}
}
SummaryIn seven healthy male volunteers the effects of the pattern of dosing on the pharmacokinetics of diazepam have been studied. A cross-over design was employed that consisted of three parts: a single intravenous dose (0.1 mg/kg), and oral dosing (10 mg/day) for six days followed by an intravenous bolus (0.1 mg/kg) on the seventh day, followed by re-examination of a single intravenous dose after diazepam (D) and its major metabolite desmethyldiazepam (DD) had been completely eliminated… Expand
Pharmacokinetics of diazepam following multiple-dose oral administration to healthy human subjects
TLDR
Steady-state diazepam plasma concentration-time profiles suggested that once daily administration of the total daily dose at bedtime might be a satisfactory dosing regimen. Expand
Clearance of diazepam can be impaired by its major metabolite desmethyldiazepam
TLDR
It is concluded that high concentrations of desmethyldiazepam can influence the elimination of its parent drug diazepam by product inhibition. Expand
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Women taking oral contraceptives will have greater plasma concentrations per unit dose of both diazepam and N-desmethyldiazepam than men, on chronic administration of diazep AM, because of variation in plasma protein binding. Expand
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TLDR
It is suggested that delivery alters the disposition of diazepam and is generally associated with a postnatal re-distribution ofdiazepam into the systemic circulation. Expand
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TLDR
Diazepam and all of its common metabolites were measured in human bile, and the concentrations found were too low to produce a clinically significant enterohepatic circulation. Expand
Pharmacokinetics and anticonvulsant effects of diazepam in children with severe falciparum malaria and convulsions.
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A comparative study of the pharmacokinetics of intravenous (i.v.) and rectal (p.r.) diazepam resulted in achievement of therapeutic concentrations ofdiazepam rapidly, without significant cardio-respiratory adverse effects. Expand
Klinische Pharmakokinetik von Diazepam und seinen biologisch aktiven Metaboliten
  • U. Klotz
  • Chemistry, Biology
  • Klinische Wochenschrift
  • 2005
TLDR
The slow elimination of diazepam is dependent on the degree of plasma protein binding, the duration of the medication, the age and the liver function of the patient, but liver patients exhibit only a slightly further prolongation inT1/2(β). Expand
Acute "tolerance" to the central respiratory effects of midazolam in the dog.
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This study demonstrated acute tolerance to the central respiratory effects of midazolam in artificially ventilated dogs, anaesthetized with chloralose and paralysed with suxamethonium. Expand
Clinical Pharmacokinetics of Acamprosate
TLDR
Interaction studies have confirmed that when acamprosate is concomitantly administered with food, the amount absorbed is decreased and it is, therefore, contraindicated under such circumstances. Expand
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