Comparison of the pharmacokinetics of crinone 8% administered vaginally versus Prometrium administered orally in postmenopausal women(3).

@article{Levine2000ComparisonOT,
  title={Comparison of the pharmacokinetics of crinone 8\% administered vaginally versus Prometrium administered orally in postmenopausal women(3).},
  author={H. Levine and N. Watson},
  journal={Fertility and sterility},
  year={2000},
  volume={73 3},
  pages={
          516-21
        }
}
OBJECTIVE Compare the pharmacokinetics of vaginal progesterone gel (Crinone 8%, 90 mg) with that of oral progesterone (Prometrium, 100 mg). DESIGN Open-label, randomized, parallel-group protocol. SETTING Outpatient clinic. PATIENT(S) Twelve healthy postmenopausal women. INTERVENTION(S) Six subjects each were randomized to receive progesterone, which was administered either as 90 mg of progesterone gel (Crinone 8%) given vaginally or 100 mg progesterone in a capsule (Prometrium) given… Expand
Single and multidose pharmacokinetic study of a vaginal micronized progesterone insert (Endometrin) compared with vaginal gel in healthy reproductive-aged female subjects.
TLDR
Endometrin vaginal inserts reached higher Cmax, produced greater systemic exposure (area under the curve 0-24), achieved steady state more rapidly, and cleared more rapidly after termination of therapy than the comparator. Expand
Pharmacokinetic Properties of Three Forms of Vaginal Progesterone Administered in Either Single Or Multiple Dose Regimen in Healthy Post-menopausal Chinese Women
TLDR
Results with single and multiple doses of vaginal progesterone gel suggest similar pharmacokinetics properties between test formulations and Crinone 8%, and overall, vaginal progestersone gel was well tolerated. Expand
Effects of estradiol with oral or intravaginal progesterone on risk markers for breast cancer in a postmenopausal monkey model
TLDR
Despite different pharmacodynamic profiles, oral and intravaginal P4 had similar effects on biomarkers in the postmenopausal breast. Expand
Transdermal Delivery of Bioidentical Progesterone with a Steroid 5α-Reductase Inhibitor (Dutasteride): a Pilot Study
TLDR
The average serum and salivary progesterone concentration, Cmax, and the AUC were slightly higher in the dutasteride group, but no significant difference could be noted. Expand
Transdermal progesterone cream as an alternative progestin in hormone therapy.
TLDR
Preliminary data indicate that CEE/PC has a similar effect on the endometrium as standard oral HT over a 6-month period. Expand
Twice-weekly transdermal estradiol and vaginal progesterone as continuous combined hormone replacement therapy in postmenopausal women: a 1-year prospective study.
TLDR
Transdermal estradiol and a twice-weekly administration of the vaginal progesterone gel Crinone constitutes a new, viable hormone replacement therapy regimen that represents a practical option for a no-bleed treatment, ensuring both high endometrial protection and the inherent safety linked to administrating physiologic hormones nonorally. Expand
Efficacy and tolerability of vaginal progesterone capsules (Utrogest 200) compared with progesterone gel (Crinone 8%) for luteal phase support during assisted reproduction.
TLDR
The luteal phase support in ART cycles with Utrogest 200 capsules or Crinone 8% gel by the vaginal route resulted in similar outcomes with respect to implantation, ongoing pregnancy, and abortion rates. Expand
Effect of oral micronized progesterone on androgen levels in women with polycystic ovary syndrome.
TLDR
It is concluded that the administration of OMP to induce withdrawal bleeding in women with PCOS does not significantly alter circulating androgen or 17-OHP levels, and can be used to time blood sampling in these patients. Expand
Comparison the Effectiveness of Oral Dydrogesterone, Vaginal Progesterone Suppository and Progesterone Ampule for Luteal Phase Support on Pregnancy Rate during ART Cycles
TLDR
The findings showed that the efficacy of oral dydrogesterone is comparable with vaginal progester one and progesterone ampule for luteal phase support in ART cycles in terms of pregnancy rate and miscarriage rate. Expand
Luteal phase support using either Crinone 8% or Utrogest: results of a prospective, randomized study.
TLDR
A prospective, randomized study investigated 126 patients undergoing cycles of in vitro fertilization and IVF/intracytoplasmic sperm injection and found that Crinone 8% had a clear advantage over Utrogest as it resulted in less vaginal discharge and fewer application difficulties. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 30 REFERENCES
The absorption of oral micronized progesterone: the effect of food, dose proportionality, and comparison with intramuscular progesterone.
TLDR
Absorption of micronized P was enhanced twofold in the presence of food and both absorption and elimination were dose-independent, dose proportionality being confirmed. Expand
Bioavailability of oral micronized progesterone.
TLDR
All subjects exhibited significant elevation of P over baseline levels that persisted for at least 6 hours after the single oral dose and returned to initial levels by 24 hours, and Serial determinations of serum P concentrations demonstrated rapid absorption of P. Expand
Pharmacokinetics and endometrial tissue levels of progesterone after administration by intramuscular and vaginal routes: a comparative study.
TLDR
Vaginal micronized P enhances P delivery to the uterus compared with a standard IM regimen and results in a synchronous secretory endometrial histology in agonadal women preparing for embryo donation. Expand
Transvaginal Administration of Progesterone
Objective To examine the endometrial effects of three different doses of progesterone administered vaginally Methods Forty women 25–41 years old deprived of ovarian function received estradiol (E2)Expand
Radioimmunoassay of plasma progesterone after oral administration of micronized progesterone.
TLDR
The separation of P from its metabolites by an adequate chromatographic system appears mandatory after oral administration of micronized P. Expand
Serum levels of progesterone and some of its metabolites including deoxycorticosterone after oral and parenteral administration
TLDR
Oral treatment with natural progesterone may develop into a n attractive alternative to synthetic progestogens but the conversion of progestersone into a potent mineralocorticoid may be a potential disadvantage. Expand
Profiles of plasma estrogens, progesterone and their metabolites after oral or vaginal administration of estradiol or progesterone.
TLDR
The vaginal route appears to be more adequate than the oral one for hormone replacement therapy for premenopausal women, in view of the metabolic pathways which are operative and of the peripheral plasma levels which were found. Expand
Variations de la progestérone plasmatique induites par l'administration vaginale d'Utrogestan®
TLDR
Vaginal administration of 100 mg of progesterone (1 Utrogestan tablet) resulted in an increase in blood progestersone levels within an hour and was the most worth-while dosage and the one recommended by the authors of this article. Expand
A prospective randomized comparison of intramuscular or intravaginal natural progesterone as a luteal phase and early pregnancy supplement.
TLDR
Intravaginal micronized progesterone was well tolerated by all patients and appeared more effective than intramuscular progester one in improving the implantation rate, and in decreasing the incidence of abortions in stimulated cycles including GnRHa. Expand
Sedative and hypnotic effects of oral administration of micronized progesterone may be mediated through its metabolites
TLDR
Levels of serum progesterone and its metabolites increased significantly from baseline values and reached a peak between 2 and 6 hours after oral progester one administration, suggesting that the sedative and hypnotic effects of oral administration of progestersone may be mediated through those compounds. Expand
...
1
2
3
...