Comparison of the pharmacokinetic properties of bisoprolol and carvedilol in healthy dogs.

@article{Beddies2008ComparisonOT,
  title={Comparison of the pharmacokinetic properties of bisoprolol and carvedilol in healthy dogs.},
  author={Gerald Beddies and Philip R Fox and Mark D Papich and Venkata-Rangaro Kanikanti and Ralph Krebber and Bruce W. Keene},
  journal={American journal of veterinary research},
  year={2008},
  volume={69 12},
  pages={1659-63}
}
OBJECTIVE To compare the pharmacokinetic properties and bioavailability following oral and IV administration of bisoprolol, a second-generation beta1-adrenoceptor-selective blocking agent, with those of carvedilol, a third-generation beta1/beta2 and alpha1-adrenoceptor blocking agent, in dogs. ANIMALS 12 healthy adult Beagles. PROCEDURES A prospective, parallel group study was performed. The dogs were allocated to 1 of 2 groups (6 dogs/group) and were administered orally a 1 mg/kg dose of… CONTINUE READING

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