Comparison of the mitogenic activity of angiotensin II and serotonin on porcine arterial smooth muscle cells.

@article{Parrott1991ComparisonOT,
  title={Comparison of the mitogenic activity of angiotensin II and serotonin on porcine arterial smooth muscle cells.},
  author={Daniel Parrott and P. Lockey and Corinne Bright},
  journal={Atherosclerosis},
  year={1991},
  volume={88 2-3},
  pages={
          213-8
        }
}
We have investigated the growth promoting activities of two potent vasoactive substances, serotonin and angiotensin II (AII), on cultured porcine aortic smooth muscle cells (ASMC), using a defined serum-free medium. Serotonin (30 nM to 30 microM) stimulated ASMC DNA synthesis both alone and in combination with platelet-derived growth factor (PDGF) and epidermal growth factor (EGF). Serotonin-induced DNA synthesis was significantly inhibited by ketanserin (5-hydroxytryptamine-2 (5HT-2) receptor… CONTINUE READING
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