Comparison of the metabolism of 2,4-toluenediamine in rats and mice.

  title={Comparison of the metabolism of 2,4-toluenediamine in rats and mice.},
  author={P. H. Grantham and L. Mohan and T. Benjamin and P. Roller and J. R. Miller and E. Weisburger},
  journal={Journal of environmental pathology and toxicology},
  volume={3 1-2},
The excretion, distribution, and metabolism of 2,4-toluenediamine (TDA) have been compared in rats and mice. The elimination of TDA metabolites into urine was faster and more complete in mice than in rats. However, the feces of rats accounted for a greater percentage of the dose in rats than in mice. The distribution of metabolites in tissues were considerably lower in mice than in rats. The major urinary metabolites observed in the rat were 4-acetylamino-2-aminotoluene, 2,4… Expand
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A physiologically based pharmacokinetic model for 2,4-toluenediamine leached from polyurethane foam-covered breast implants.
Physiologically based pharmacokinetic (PBPK) modeling was used to assess the low-dose exposure of patients to the carcinogen 2, 4-toluenediamine (2,4-TDA) released from the degradation of theExpand
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Hemoglobin adducts of N-substituted aryl compounds in exposure control and risk assessment.
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Scientific Basis for Swedish Occupational Standards XXII
In studies in which pregnant pigs and rats were fed on cassava containing up to 1250 mg KCN/kg, the only observed toxic effects on reproduction were minor metabolic differences and lower relative organ weights in fetuses at doses affecting the mothers. Expand
Subjects Evaluation Conduct of the Study Collection of Biological Samples for Screening Collection of Biological Samples for Measurement of 2 , 4-TDA , 2 , 6-TDA , and 4-Acetyl-TDA Sample Analysis Risk Assessment Results Patient Surveys Serum Analysis
  • 2009
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Development of an Animal Model for Testing Human Breast Implantation Materials
Histologic findings in the present study are strikingly similar to the human response to polyurethane-coated breast implants, suggesting the applicability of this model to appropriately test mammaplasty materials in mammary tissues. Expand
Vetenskapligt underlag för hygieniska gränsvärden. : 22
An English version "Scientific Basis for Swedish Occupational Standards XXIX" will be published in Arbete och Halsa 2009.