Comparison of the metabolism of 2,4-toluenediamine in rats and mice.

@article{Grantham1979ComparisonOT,
  title={Comparison of the metabolism of 2,4-toluenediamine in rats and mice.},
  author={P. H. Grantham and L. Mohan and T. Benjamin and P. Roller and J. R. Miller and E. Weisburger},
  journal={Journal of environmental pathology and toxicology},
  year={1979},
  volume={3 1-2},
  pages={
          149-66
        }
}
The excretion, distribution, and metabolism of 2,4-toluenediamine (TDA) have been compared in rats and mice. The elimination of TDA metabolites into urine was faster and more complete in mice than in rats. However, the feces of rats accounted for a greater percentage of the dose in rats than in mice. The distribution of metabolites in tissues were considerably lower in mice than in rats. The major urinary metabolites observed in the rat were 4-acetylamino-2-aminotoluene, 2,4… Expand
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