Comparison of the metabolic effects of sustained CCK1 receptor activation alone and in combination with upregulated leptin signalling in high-fat-fed mice

@article{Irwin2013ComparisonOT,
  title={Comparison of the metabolic effects of sustained CCK1 receptor activation alone and in combination with upregulated leptin signalling in high-fat-fed mice},
  author={Nigel Irwin and Ian Montgomery and Peter Raymond Flatt},
  journal={Diabetologia},
  year={2013},
  volume={56},
  pages={1425-1435}
}
Cholecystokinin (CCK) and leptin are important hormones with effects on energy balance. The present study assessed the biological effects of (pGlu-Gln)-CCK-8 and [d-Leu-4]-OB3, smaller isoforms of CCK and leptin, respectively. The actions and overall therapeutic use of (pGlu-Gln)-CCK-8 and [d-Leu-4]-OB3, alone and in combination, were evaluated in normal and high-fat-fed mice. (pGlu-Gln)-CCK-8 had prominent (p < 0.01 to p < 0.001), acute feeding-suppressive effects, which were significantly… CONTINUE READING
2 Citations
50 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 50 references

Similar Papers

Loading similar papers…