Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties.

  title={Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties.},
  author={Tian Xia and Michael Kovochich and Monty Liong and Lutz M{\"a}dler and Benjamin Gilbert and Haibin Shi and Joanne I. Yeh and Jeffrey I. Zink and Andre E. Nel},
  journal={ACS nano},
  volume={2 10},
Nanomaterials (NM) exhibit novel physicochemical properties that determine their interaction with biological substrates and processes. Three metal oxide nanoparticles that are currently being produced in high tonnage, TiO(2), ZnO, and CeO(2), were synthesized by flame spray pyrolysis process and compared in a mechanistic study to elucidate the physicochemical characteristics that determine cellular uptake, subcellular localization, and toxic effects based on a test paradigm that was originally… 

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