Corpus ID: 23247565

Comparison of the mechanism of action of cyclic 11,12-erythromycin A carbonate and erythromycin A.

@article{Klita1980ComparisonOT,
  title={Comparison of the mechanism of action of cyclic 11,12-erythromycin A carbonate and erythromycin A.},
  author={S. Klita and P. Szafranski},
  journal={Acta biochimica Polonica},
  year={1980},
  volume={27 3-4},
  pages={
          213-20
        }
}

S. Klita, P. Szafranski

Published 1980

Chemistry, Medicine

Acta biochimica Polonica

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Synthesis of polyphenylalanine and polylysine in the E. coli MRE 600 and Q 13 cell-free systems was inhibited by erythromycin A and cyclic 11, 12-erythromycin A carbonate to a similar or identical extent. Both compounds inhibited translation of phage f2 RNA in the E. coli Q13 cell-free system. Neither antibiotic affected binding of initiator tRNA or phage f2 RNA to E. coli ribosomes, and neither inhibited translation of BMV RNA in the wheat-germ cell-free system.