Comparison of the kinetics of glyburide and its active metabolites in humans.

@article{Rydberg1995ComparisonOT,
  title={Comparison of the kinetics of glyburide and its active metabolites in humans.},
  author={Tony Rydberg and Anders J{\"o}nsson and Arne Melander},
  journal={Journal of clinical pharmacy and therapeutics},
  year={1995},
  volume={20 5},
  pages={283-95}
}
The pharmacokinetics of glyburide (Gb) and its active metabolites, 4-trans-hydroxyglibenclamide (M1) and 3-cis-hydroxyglibenclamide (M2), were compared in eight healthy subjects. After an overnight fast, each subject received a 3.5-mg single dose of Gb, M1 or M2 intravenously in random cross-over order. For comparison, a 3.5-mg oral dose of micronized formulation of Gb was also given in a test. The subjects continued to fast until standard meals were given at 0.5 and 5.5 h after each dose… CONTINUE READING

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