Comparison of the intravenous reinforcing effects of propofol and methohexital in baboons.

@article{Weerts1999ComparisonOT,
  title={Comparison of the intravenous reinforcing effects of propofol and methohexital in baboons.},
  author={Elise M Weerts and Nancy A. Ator and Roland R. Griffiths},
  journal={Drug and alcohol dependence},
  year={1999},
  volume={57 1},
  pages={51-60}
}
Propofol is a widely used intravenous anesthetic that can directly activate and positively modulate the GABA(A)-receptor. Propofol is not currently regulated under the USA Controlled Substances Act. The present study evaluated the intravenous reinforcing effects of propofol compared to the intravenous barbiturate anesthetic methohexital in baboons using a procedure in which doses of the test drug were substituted for a standard cocaine dose. Drug or vehicle was available for self-injection… CONTINUE READING