Comparison of the interaction potential of a new proton pump inhibitor, E3810, versus omeprazole with diazepam in extensive and poor metabolizers of S-mephenytoin 4'-hydroxylation.

@article{Ishizaki1995ComparisonOT,
  title={Comparison of the interaction potential of a new proton pump inhibitor, E3810, versus omeprazole with diazepam in extensive and poor metabolizers of S-mephenytoin 4'-hydroxylation.},
  author={Takashi Ishizaki and Kan Chiba and Ken-ichi Manabe and E. Koyama and Masahiro Hayashi and Susumu Yasuda and Yukio Horai and Yumiko Tomono and C Yamato and T Toyoki},
  journal={Clinical pharmacology and therapeutics},
  year={1995},
  volume={58 2},
  pages={155-64}
}
OBJECTIVE To compare the interaction potential of E3810, [(+/-)-sodium 2-[[4-(3-methoxpropoxy)-3-methylpyridin-2-yl]methylsulfinyl] -1H-benzimidazole] a new proton pump inhibitor, and omeprazole with diazepam in relation to S-mephenytoin 4'-hydroxylation status. STUDY DESIGN Fifteen healthy male volunteers consisting of six poor metabolizers and nine extensive metabolizers of S-mephenytoin 4'-hydroxylation participated in the study, where two poor and three extensive metabolizers each as a… CONTINUE READING