Comparison of the in vitro cytotoxicities and acute in vivo toxicities of 59 chemicals.

@article{Clothier1987ComparisonOT,
  title={Comparison of the in vitro cytotoxicities and acute in vivo toxicities of 59 chemicals.},
  author={Richard H Clothier and L M Hulme and Martha Smith and Michael Balls},
  journal={Molecular toxicology},
  year={1987},
  volume={1 4},
  pages={571-7}
}
The in vitro cytotoxicities of 59 chemicals, expressed as ID50 values (i.e., concentrations of test chemicals that reduced the final cellular protein content of test cultures by 50% in comparison with appropriate solvent control cultures) and obtained using murine 3T3-L1 cells and the FRAME kenacid blue method, have been compared with rat oral and mouse intraperitoneal (ip) LD50 values. A better in vivo/in vitro correlation was obtained for the 59 chemicals with mouse ip LD50 values (r = .80… CONTINUE READING

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