Comparison of the growth of virulent and attenuated strains of Candida albicans in the kidneys of normal and cortisone-treated mice by Chitin assay

@article{White2004ComparisonOT,
  title={Comparison of the growth of virulent and attenuated strains of Candida albicans in the kidneys of normal and cortisone-treated mice by Chitin assay},
  author={Les O. White and Ellen Gibb and Helen C. Newham and Malcolm D Richardson and Richard C. Warren},
  journal={Mycopathologia},
  year={2004},
  volume={67},
  pages={173-177}
}
Candida albicans strain 22114 was avirulent for mice compared with strain 19321 in that, administered intravenously, 106 blastospores of 22114 failed to kill whereas 106 blastospores of 19321 produced 100% mortality. Cortisone treatment rendered mice susceptible to killing by 22114. Chitin assay showed that cortisone stimulated the growth of both strains in the mouse kidney. Growth of 19321 was increased up to five-fold and 22114 up to forty-fold. The strains may have differential… Expand
3 Citations
Killing of yeast, germ-tube and mycelial forms of Candida albicans by murine effectors as measured by a radiolabel release microassay.
TLDR
It is shown that hyphal forms were killed by murine effectors to a similar, if not greater, extent than yeast forms, and thioglycollate-induced murine polymorphonuclear neutrophils were able to kill hyphal cells extracellularly and without an opsonic requirement. Expand
Tissue responses to the blastospores and hyphae of Candida albicans in the mouse.
  • Z. A. Evans
  • Biology, Medicine
  • Journal of medical microbiology
  • 1981
TLDR
It is indicated that lungs may play a more important role than other reticuloendothelial organs in innate resistance to vascular invasion by either of the morphological forms of C. albicans, and macrophages may be crucial to host resistance to renal invasion by this fungus. Expand
TISSUE RESPONSES TO THE BLASTOSPORES AND HYPHAE O F C A N D I D A ALBZCANS IN THE MOUSE
Separate groups of mice challenged intravenously with either the blastospore or hyphal forms of the same strain of Candida albicans were examined for comparative mortality rates, organ localisation,Expand

References

SHOWING 1-10 OF 16 REFERENCES
Studies on the pathogenesis of experimental Candida albicans infections in mice
TLDR
After intravenous infection with six strains of Candida albicans, the kidney was the only tissue in which infection progressed, and transformation into the mycelial phase was followed by progressive infection only in the kidney. Expand
Organ Localization in Mice Challenged with a Typical Candida albicans Strain and a Pseudohyphal Variant 1
  • Z. A. Evans, D. Mardon
  • Biology, Medicine
  • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1977
TLDR
The data support the premise that disseminating systemic C. albicans infections are more likely to be initiated by the yeast-like form of the microorganism and indicate that the lungs may play a vital role in innate host resistance against vascular dissemination of C.Albicans. Expand
Chitin assay used to demonstrate renal localization and cortisone-enhanced growth of Aspergillus fumigatus mycelium in mice
TLDR
It is suggested that the resistance of N-mice to mycelial development may be an important mechanism whereby natural resistance to A. fumigatus is conferred. Expand
Experimental Candida albicans Infection in Conventional Mice and Germfree Rats
Swiss-Webster white mice were intravenously infected with various doses of Candida albicans, and the viable units in their spleens, livers, lungs, and kidneys were determined at various intervalsExpand
Experimental Candida albicans infection in conventional mice and germfree rats
Swiss-Webster white mice were intravenously infected with various doses of Candida albicans, and the viable units in their spleens, livers, lungs, and kidneys were determined at various intervalsExpand
Experimental renal candidiasis in mice and guinea pigs.
  • B. Winblad
  • Biology, Medicine
  • Acta pathologica et microbiologica Scandinavica. Section A, Pathology
  • 1975
TLDR
The pathogenesis of renal candidiasis seems to resemble that of renal tuberculosis, and two types of the disease could be distinguished: an acute type with cortical abscesses and a chronic type with partly necrotic tips of the pyramids and adhering fungal masses in the pelves. Expand
Estimation of Absidia ramosa infection in the brain and kidneys of cortisone-treated mice by chitin assay
Chitin assay was used to measure Absidia ramosa infection in the brain and kidneys of cortisone-treated mice. Mice dying 3 days after challenge had brain and kidney infection but normal renalExpand
Interaction of Candida albicans with human leukocytes and serum.
TLDR
The data suggest that the neutrophils can play an important role in resistance to Candida infection and that the lysosomal enzyme myeloperoxidase and its oxidant substrate hydrogen peroxide are the major participants in neutrophil candidacidal activity. Expand
Experimental visceral aspergillosis.
TLDR
The authors' studies indicate that phagocytic cells in the peritoneal cavity of normal mice are able to ingest nonperminating spores of Aspergillus flavus and kill them, preventing germination, but are unable to cope with early germinate spores, which then continue to proliferate, leading to extensive hyphal invasion of visceral organs and death. Expand
Cell wall composition of the mycelial and blastospore forms of Candida albicans.
TLDR
The composition of the wall of each form was found to be constant, irrespective of growth conditions, except for some variation in the amounts of mannose and glucose in wall hydrolysates. Expand
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