Comparison of the global gene expression profiles produced by methylparaben, n‐butylparaben and 17β‐oestradiol in MCF7 human breast cancer cells

@article{Pugazhendhi2007ComparisonOT,
  title={Comparison of the global gene expression profiles produced by methylparaben, n‐butylparaben and 17$\beta$‐oestradiol in MCF7 human breast cancer cells},
  author={Dhamayanthi Pugazhendhi and A. J. Sadler and Philippa D Darbre},
  journal={Journal of Applied Toxicology},
  year={2007},
  volume={27}
}
Since the alkyl esters of p‐hydroxybenzoic acid (parabens) can be measured intact in the human breast and possess oestrogenic properties, it has been suggested that they could contribute to an aberrant burden of oestrogen signalling in the human breast and so play a role in the rising incidence of breast cancer. However, although parabens have been shown to regulate a few single genes (reporter genes, pS2, progesterone receptor) in a manner similar to that of 17β‐oestradiol, the question… 
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References

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TLDR
It can be concluded that removal of the ester group from parabens does not abrogate its oestrogenic activity and that p‐hydroxybenzoic acid can give oestrogensic responses in human breast cancer cells.
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TLDR
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TLDR
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