Comparison of the expression of a mutant dihydrofolate reductase under control of different internal promoters in retroviral vectors.

@article{Li1992ComparisonOT,
  title={Comparison of the expression of a mutant dihydrofolate reductase under control of different internal promoters in retroviral vectors.},
  author={Ming Li and Petros A. Hantzopoulos and Debabrata Banerjee and Sheng Chuan Zhao and Barry I Schweitzer and Eli Gilboa and Joseph R. Bertino},
  journal={Human gene therapy},
  year={1992},
  volume={3 4},
  pages={
          381-90
        }
}
To determine the effect of different promoters on the expression of an altered dihydrofolate reductase (DHFR) gene conferring methotrexate (MTX) resistance in different cell types, double-copy retroviral vectors were constructed carrying a murine mutant DHFR under the control of five different promoters, i.e., human adenosine deaminase (ADA), simian virus 40 (SV40), thymidine kinase (TK), human beta-actin, and cytomegalovirus (CMV). Their expression was compared in NIH-3T3 cells, three human… CONTINUE READING
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