Comparison of the electrophysiologic effects of intravenous and oral lorcainide in patients with recurrent ventricular tachycardia.

@article{Echt1983ComparisonOT,
  title={Comparison of the electrophysiologic effects of intravenous and oral lorcainide in patients with recurrent ventricular tachycardia.},
  author={D. Echt and L. Mitchell and R. Kates and R. Winkle},
  journal={Circulation},
  year={1983},
  volume={68 2},
  pages={
          392-9
        }
}
  • D. Echt, L. Mitchell, +1 author R. Winkle
  • Published 1983
  • Medicine
  • Circulation
  • The electrophysiologic effects of intravenous lorcainide (2.2 mg/kg) in 10 patients were compared with the electrophysiologic effects of oral lorcainide (mean dose 400 mg/day for 8 days) in 11 patients, all with recurrent ventricular tachycardia that could be induced with programmed stimulation. Intravenous and oral lorcainide resulted in similar prolongation of the QRS, QT, and HV intervals, but only oral lorcainide resulted in prolongation of the AH interval and atrial and ventricular… CONTINUE READING
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    Lorcainide for the Treatment of Refractory Ventricular Tachycardia: Clinical and Electrophysiologic Results
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    References

    SHOWING 1-10 OF 19 REFERENCES
    Lorcainide; II. Plasma concentration‐effect relationship
    • 60
    Comparative Electrophysiology of Lorcainide and Norlorcainide in the Dog
    • 10
    Antiarrhythmic, electrophysiologic and hemodynamic effects of lorcainide.
    • 47
    Lorcainide disposition kinetics in arrhythmia patients
    • 26
    Electrophysiology of oral encainide.
    • 86
    Disposition kinetics of lorcain - ide in arrhythmia patients
    • Clin Pharmacol Ther
    • 1982
    Pharmacodynam - ics of the initiation of oral lorcainide therapy
    • Circulation
    • 1982