Comparison of the efficiency of complexes based on S4(13)-PV cell-penetrating peptides in plasmid DNA and siRNA delivery.

@article{Cardoso2013ComparisonOT,
  title={Comparison of the efficiency of complexes based on S4(13)-PV cell-penetrating peptides in plasmid DNA and siRNA delivery.},
  author={Ana Maria Sequeira Cardoso and Sara Trabulo and Ana Luisa Colaco Cardoso and S{\'i}lvia R Maia and Paula Gomes and Am{\'a}lia S. Jurado and Maria Conceiç{\~a}o Pedroso de Lima},
  journal={Molecular pharmaceutics},
  year={2013},
  volume={10 7},
  pages={
          2653-66
        }
}
The successful application of gene therapy approaches is highly dependent on the efficient delivery of nucleic acids into target cells. In the present study, new peptide-based nonviral systems were developed to enhance plasmid DNA and siRNA delivery, aiming at generating appropriate gene delivery and gene silencing tools for preclinical and clinical application. For this purpose, a new cell-penetrating peptide derived from the wild-type S4(13)-PV peptide was synthesized through the addition of… CONTINUE READING
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