Comparison of the efficacy of early versus late viral proteins in vaccination against SIV.

@article{Stittelaar2002ComparisonOT,
  title={Comparison of the efficacy of early versus late viral proteins in vaccination against SIV.},
  author={Koert J. Stittelaar and Rob A. Gruters and Martin Schutten and Carel A. van Baalen and Geert van Amerongen and Martin P. Cranage and Peter Liljestr{\"o}m and Gerd Sutter and Albert D M E Osterhaus},
  journal={Vaccine},
  year={2002},
  volume={20 23-24},
  pages={2921-7}
}
The immune response against early regulatory proteins of simian- and human immunodeficiency virus (SIV, HIV) has been associated with a milder course of infection. Here, we directly compared vaccination with Tat/Rev versus Pol/Gag. Challenge infection with SIVmac32H (pJ5) suggested that vaccination with Tat/Rev induced cellular immune responses that enabled cynomolgus macaques to more efficiently control SIV replication than the vaccine-induced immune responses against Pol/Gag. Vaccination with… CONTINUE READING