Comparison of the efficacy and tolerability of a paracetamol/codeine fixed-dose combination with tramadol in patients with refractory chronic back pain.

@article{Mueller1998ComparisonOT,
  title={Comparison of the efficacy and tolerability of a paracetamol/codeine fixed-dose combination with tramadol in patients with refractory chronic back pain.},
  author={Fred O Mueller and C L Odendaal and Felix R. M{\"u}ller and J Raubenheimer and Michelle Vivienne Middle and Michael Kummer},
  journal={Arzneimittel-Forschung},
  year={1998},
  volume={48 6},
  pages={675-9}
}
Fifty-five patients suffering from refractory chronic back pain took part in a double-blind, multiple-dose, randomised, cross-over study to compare the efficacy and tolerability of a fixed-dose capsule preparation containing 500 mg paracetamol (CAS 103-90-2) and 30 mg codeine phosphate 1/2 H2O (CAS 41444-62-6) (talvosilen forte, test preparation) with a reference capsule preparation containing 50 mg tramadol hydrochloride (CAS 22204-88-2), in a regimen of two capsules 8-hourly. There were two… CONTINUE READING