Comparison of the effects of the antiestrogens EM-800 and tamoxifen on the growth of human breast ZR-75-1 cancer xenografts in nude mice.

@article{Couillard1998ComparisonOT,
  title={Comparison of the effects of the antiestrogens EM-800 and tamoxifen on the growth of human breast ZR-75-1 cancer xenografts in nude mice.},
  author={Steeve Couillard and Matthieu Gutman and Claude Labrie and Alain B{\'e}langer and Bernard Candas and Fernand Labrie},
  journal={Cancer research},
  year={1998},
  volume={58 1},
  pages={60-4}
}
Although estrone supplementation in ovariectomized (OVX) nude mice bearing ZR-75-1 xenografts caused a 365% increase in average tumor size during the 4-month treatment period, administration of the antiestrogen EM-800 at the daily oral doses of 50, 150, or 400 microg completely prevented estrogen-stimulated tumor growth. At the same doses of tamoxifen, tumor size was inhibited to 189, 117, and 120% above pretreatment values. However, when EM-800 (150 microg/day) was added to the daily 150- and… CONTINUE READING
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Highly potent and pure antiestrogenic activity of a new antiestrogen on human ZR - 75 †” 1 breast tumors in nude mice

  • S. Couillard, C. Labrie, S. Gauthier, Y. MÃ © rand, F. Labrie
  • 1996

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