Comparison of the effects of several potassium-channel openers on rat bladder and rat portal vein in vitro.

@article{Edwards1991ComparisonOT,
  title={Comparison of the effects of several potassium-channel openers on rat bladder and rat portal vein in vitro.},
  author={Gillian Edwards and Michelle M. Henshaw and Marion Hemmersbach Miller and Arthur H. Weston},
  journal={British journal of pharmacology},
  year={1991},
  volume={102 3},
  pages={679-86}
}
1. The ability of several K-channel openers to inhibit KCl-induced contractions of rat bladder detrusor and spontaneous mechanical activity in rat portal vein was examined. 2. Lemakalim, pinacidil, Ro 31-6930, RP 49356, P1060 and S 0121 dose-dependently relaxed rat detrusor, precontracted with 20 mM KCl. With the exception of pinacidil, concentrations of these agents below 30 microM did not inhibit 80 mM KCl-included contractions. Pinacidil (10 microM) produced a small, but significant (P < 0… CONTINUE READING

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