Comparison of the effects of quazepam and triazolam on cognitive-neuromotor performance

@article{Nikaido2004ComparisonOT,
  title={Comparison of the effects of quazepam and triazolam on cognitive-neuromotor performance},
  author={Arlene M. Nikaido and E. H. Ellinwood},
  journal={Psychopharmacology},
  year={2004},
  volume={92},
  pages={459-464}
}
The pharmacological activity of quazepam, a BZ1 specific benzodiazepine, was compared to the effects of triazolam, a BZ1, BZ2 nonspecific benzodiazepine. Using a double-blind procedure, single oral doses of quazepam (15 or 30 mg), triazolam (0.5 or 1.0 mg) and placebo were administered to 21 healthy young men according to a random Latin square design balanced for order of drug administration. The drug effects on the performance of motor coordination and cognitive tasks were monitored for 7 h… 
Comparison of hangover effects among triazolam, flunitrazepam and quazepam in healthy subjects: A preliminary report
TLDR
Subjective hangover effects assessed by SSS and SEQ in the morning were prominent for flunitrazepam and quazepam relative to triazolam, whereas objective indices such as MSLT or activity counts obtained in actigraphy indicated a marked hangover effect of quazEPam compared with the other two compounds restrictively in the afternoon, which were nearly in accordance with their pharmacokinetic profiles.
Reintroduction of quazepam: an update on comparative hypnotic and adverse effects.
  • N. Moniri
  • Psychology, Biology
    International clinical psychopharmacology
  • 2019
TLDR
The purpose of this review is to provide an update on distinguishing features of quazepam with regard to its pharmacology, pharmacokinetics, sleep efficacy and potential adverse effects compared to other agents used for insomnia.
The effects of acute treatment with ramelteon, triazolam, and placebo on driving performance, cognitive function, and equilibrium function in healthy volunteers
TLDR
Ramelteon may affect road-tracking performance, visual attention and/or psychomotor speed measured by Trail-Making Test part A, and body balance in acute dosing, and Physicians should consider risks and benefits when prescribing both drugs.
Study of the potential reversal of triazolam memory and cognitive deficits by RU 41 656 in healthy subjects
TLDR
Under the experimental conditions of the trial, RU 41 656 failed to counteract the memory deficits induced by triazolam, as already described with other benzodiazepine with few sedative effects at this dosage.
Interaction between grapefruit juice and hypnotic drugs: comparison of triazolam and quazepam
TLDR
Grapefruit juice (GFJ) inhibits cytochrome P450 (CYP) 3A4 in the gut wall and increases blood concentrations of CYP3A4 substrates by the enhancement of oral bioavailability and suggests that the effects of GFJ on the pharmacodynamics of triazolam are greater than those on quazepam.
Effects of oxazepam on eye movements and performance in vigilance tasks with static and dynamic stimuli
TLDR
There were dose-dependent effects of oxazepam on absolute, overall level of performance but not on the decrement with time, and the non-dose-dependent aggravation of the decrements in correct detections could only partly be accounted for by pharmacokinetics and increased eyelid closures, and was also caused by pharmacodynamic effects of the drug, such as those on attention.
The pharmacology of benzodiazepines: comments on terminology and sources of data
TLDR
When a benzodiazepine is discontinued after chronic treatment, pharmacokinetic elimination half-life is the major determinant of the intensity and time-course of discontinuation syndromes.
The Effects of Fall-Risk-Increasing Drugs on Postural Control: A Literature Review
TLDR
It can be concluded that psychotropic drugs cause impairments in postural control, which is probably one of the mediating factors for the increased fall risk these FRIDs are associated with.
...
1
2
...

References

SHOWING 1-10 OF 28 REFERENCES
The acute effect of quazepam on the sleep of chronic insomniacs. A dose-response study.
TLDR
The results indicated that daily administration of quazepam over three nights produced increased effects on sleep which suggested drug accumulation, and the accumulation of the parent compound or its active metabolites thus seemed to mediate these effects onSleep in a dose related fashion.
Comparative pharmacokinetics and pharmacodynamics of lorazepam, alprazolam and diazepam
TLDR
The effects of clinically equipotent doses of lorazepam, alprazolam, and diazepam on the performance of tracking and digit symbol substitution tasks are contrasted to highlight the need to consider receptor kinetics as an important factor in benzodiazepine pharmacodynamics.
The sedative-hypnotic properties of quazepam, a new hypnotic agent.
TLDR
In conscious, unrestrained squirrel monkeys and cats, quazepam produced sedation with less ataxia and less evidence of CNS stimulant action than flurazepAM, which should be an effective hypnotic with less potential for ataxIA, paradoxical excitation, and tolerance than florinol.
The Effect of a Single Dose of Quazepam (Sch-16134) on the Sleep of Chronic Insomniacs
TLDR
The results indicate that a single dose of quazepam administered for one night was efficacious when measured both objectively by polysomnographic recording and subjectively by questionnaire with no reported side-effects.
Quazepam, A New Benzodiazepine Hypnotic: Intermediate‐Term Sleep Laboratory Evaluation
TLDR
Data regarding long-term safety or tolerance of the drug suggest that quazepam is well tolerated and that its pharmacological effects are similar to those of other benzodiazepines.
Comparison of quazepam, flunitrazepam and placebo as single-dose hypnotics before surgery
SummaryThe hypnotic effect and tolerance of quazepam (Sch 16134) 15 and 30 mg, flunitrazepam 1 and 2 mg and placebo were evaluated in a one-night, randomized, double-blind, parallel group study of
Quazepam and flurazepam: Long‐term use and extended withdrawal
TLDR
The data suggest that the optimal dose of quazepam is 15 mg, and some loss of effectiveness was noted during long‐term use of both doses of quzepam and, to a lesser extent, of flurazepams.
Quazepam in the short-term treatment of insomnia in outpatients.
TLDR
Overall, quazepam 30 mg was a safe and effective hypnotic, with significant hypnotic activity on the first night of administration.
Short-term treatment with quazepam of insomnia in geriatric patients.
TLDR
The resuls confirm that quazepam in a dosage of 15 mg/night is safe and that it is more effective than placebo in treating insomnia in older patients.
Short-term treatment with quazepam of insomnia in geriatric patients.
TLDR
The resuls confirm that quazepam in a dosage of 15 mg/night is safe and that it is more effective than placebo in treating insomnia in older patients.
...
1
2
3
...