Comparison of the effects of low molecular weight heparin and unfractionated heparin on activation of human platelets in vitro.

@article{Westwick1986ComparisonOT,
  title={Comparison of the effects of low molecular weight heparin and unfractionated heparin on activation of human platelets in vitro.},
  author={John Westwick and Michael F. Scully and Christopher T. Poll and Vijay Vir Kakkar},
  journal={Thrombosis research},
  year={1986},
  volume={42 4},
  pages={435-47}
}
An unfractionated heparin (UFH) and a depolymerised derivative of low molecular weight heparin (LMWH) have been compared for their ability to activate platelets suspended in citrated plasma (PRP) or after washing and suspension in hepes buffered tyrode containing fibrinogen. Neither heparin alone induced aggregation of washed platelets, but UFH and to a much lesser extent LMWH, induced aggregation of platelets in PRP. Both heparins caused significant enhancement of a low concentration of ADP… CONTINUE READING