Comparison of the effects of intra‐arterial and aerosol administration of endothelin‐1 (ET‐1) in the guinea‐pig isolated lung

@article{Pons1991ComparisonOT,
  title={Comparison of the effects of intra‐arterial and aerosol administration of endothelin‐1 (ET‐1) in the guinea‐pig isolated lung},
  author={Françoise Pons and Caroline Touvay and Vincent Lagente and Jean Michel Mencia-Huerta and Pierre G. Braquet},
  journal={British Journal of Pharmacology},
  year={1991},
  volume={102}
}
1 Intra‐arterial injection of endothelin‐1 (ET‐1, 400 pmol; 1 μg) in guinea‐pig isolated perfused lungs, induced increases in pulmonary inflation pressure (PIP) and perfusion pressure (PPP), associated with oedema formation and thromboxane B2 (TxB2) release but not with the generation of sulphidopeptide leukotrienes or release of histamine. In contrast, aerosol administration of ET‐1 (3, 6, 10 μg ml−1, for 2 min) evoked a dose‐dependent increase in PIP, without significant changes in PPP… Expand
Bronchopulmonary responses to endothelin‐1 in sensitized and challenged guinea‐pigs: role of cyclooxygenase metabolites and platelet‐activating factor
TLDR
It is suggested that a phosphoramidon‐sensitive endopeptidase‐like enzyme, present in the airway tissue modulates the effect of ET‐1, which appears to be mediated by PAF rather than cyclooxygenase metabolites. Expand
Acute pro‐inflammatory actions of endothelin‐1 in the guinea‐pig lung: involvement of ETA and ETB receptors
TLDR
It is concluded that, in addition to evoking airway contractions, ET‐1 exerts pro‐inflammatory actions via activation of the ETA and to a lesser extent the ETB receptors, and therefore, might contribute to the airway inflammation present in asthma. Expand
Nitric oxide limits the eicosanoid‐dependent bronchoconstriction and hypotension induced by endothelin‐1 in the guinea‐pig
TLDR
Exogenous NO appears to modulate ET‐1‐induced bronchoconstriction and pressor effects in the guinea‐pig by limiting the peptide's ability to induce, possibly via ETB receptors, the release of TxA2 in the lungs and of vasodilatory prostanoids in the systemic circulation. Expand
The induction of a biphasic bronchospasm by the ETB agonist, IRL 1620, due to thromboxane A2 generation and endothelin‐1 release in guinea‐pigs
TLDR
Both phases of bronchoconstriction induced by IRL 1620 were mediated primarily by ETB receptor activation, the first phase being a consequence of TXA2 and acetylcholine release. Expand
The interaction of endothelin receptor responses in the isolated perfused rat lung
TLDR
Both ETA- and ETB-receptors contribute to ET-1-induced vasoconstriction and bronchconstriction, and simultaneous inhibition of both receptors is required to prevent the deleterious effects ofET-1 on lung functions. Expand
Role of the neutral endopeptidase 24.11 in the conversion of big endothelins in guinea‐pig lung parenchyma
TLDR
The results suggest that the effects of big ET•1 and big ET‐2 result from the conversion to ET‐1 andET‐2 by at least one enzyme sensitive to phosphoramidon, thiorphan and SQ 28,603, which could also be responsible for the degradation of ETs in the GPLP. Expand
Endothelin‐1‐induced [3H]‐inositol phosphate accumulation in rat trachea
1 The effects of endothelin‐1 (ET‐1) and of the muscarinic cholinoceptor agonist, carbachol, on [3H]‐inositol phosphate ([3H]‐InsP) accumulation and smooth muscle contraction were determined in ratExpand
Role of endothelin ETB receptors in bronchoconstrictor and vasoconstrictor responses in guinea-pigs.
TLDR
In anesthetized and ventilated guinea-pigs, intravenous injections of endothelin (ET)-1, ET-3, and [Ala1,3,11,15]ET-1, an ETB-selective receptor agonist, induced bronchoconstrictor and transient vasoconstriction responses, whilst the sustained pressor response is mediated by ETA receptors. Expand
Phosphodiesterase inhibitors prevent endothelin-1-induced vasoconstriction, bronchoconstriction, and thromboxane release in perfused rat lung.
TLDR
It is concluded that combined inhibition of PDE III and IV counteracts ET-1-elicited pressor- and inflammatory actions in the lung. Expand
Potentiation by endothelin‐1 of cholinergic nerve‐mediated contractions in mouse trachea via activation of ETB receptors
TLDR
Endothelin‐1‐induced potentiation of cholinergic nerve‐mediated contractions in mouse isolated trachea is investigated and pharmacologically the endothelin receptors mediating this response are characterized. Expand
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