Comparison of the effects of hydralazine and nifedipine on contractions and 45Ca influx of rat aorta.

@article{Orallo1991ComparisonOT,
  title={Comparison of the effects of hydralazine and nifedipine on contractions and 45Ca influx of rat aorta.},
  author={Francisco Orallo and Jos{\'e} Gil-Longo and B Bard{\'a}n and Jos{\'e} Mar{\'i}a Calleja},
  journal={The Journal of pharmacy and pharmacology},
  year={1991},
  volume={43 5},
  pages={356-9}
}
The effect of the vasodilator hydralazine has been compared with nifedipine on KCl-(K+) (60 mM) and noradrenaline-(NA) (10 microM) induced 45Ca uptake and contractile responses in rat aorta arterial strips without endothelium. Hydralazine (0.5-10 mM) was equally effective in relaxing K(+)- (IC50 = 2.2 +/- 0.17 mM) and NA- (IC50 = 3.06 +/- 0.25 mM) induced tension, the degree of relaxation depending on the dose. Nifedipine totally inhibited K(+)- (IC50 = 3.16 +/- 0.28 nM) induced contractions… CONTINUE READING