Comparison of the effects of growth hormone and insulin-like growth factor I on substrate oxidation and on insulin sensitivity in growth hormone-deficient humans.

Abstract

Insulin-like growth factor-I (IGF-I) is considered to be the mediator of the growth-promoting effects of growth hormone (GH). The metabolic effects of these two hormones, however, are different. Whereas GH treatment leads to elevated insulin and glucose levels, reduced insulin sensitivity, and impaired glucose tolerance, IGF-I treatment leads to reduced… (More)

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@article{Hussain1994ComparisonOT, title={Comparison of the effects of growth hormone and insulin-like growth factor I on substrate oxidation and on insulin sensitivity in growth hormone-deficient humans.}, author={M. A. Hussain and Ole E Schmitz and Annette Mengel and Y. Glatz and Jessie Christiansen and Jurgen Zapf and E. Rudolf Froesch}, journal={The Journal of clinical investigation}, year={1994}, volume={94 3}, pages={1126-33} }