Comparison of the effects of different routes of antipsychotic administration on pharmacokinetics and pharmacodynamics.

@article{Ereshefsky2003ComparisonOT,
  title={Comparison of the effects of different routes of antipsychotic administration on pharmacokinetics and pharmacodynamics.},
  author={Larry Ereshefsky and Cynthia A Mascarenas},
  journal={The Journal of clinical psychiatry},
  year={2003},
  volume={64 Suppl 16},
  pages={18-23}
}
Clinicians face a dilemma when choosing between short-acting atypical antipsychotics and long-acting conventional antipsychotics. Atypical antipsychotics offer better safety and efficacy, while depot formulations of conventional antipsychotics provide more reliable drug delivery, reduced differences in peak and trough plasma levels of drug, and greater dosing precision. Risperidone was recently approved by the U.S. Food and Drug Administration as the first atypical long-acting antipsychotic… CONTINUE READING

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