Comparison of the effects of dexamphetamine and 1-benzylpiperazine in former addicts

  title={Comparison of the effects of dexamphetamine and 1-benzylpiperazine in former addicts},
  author={Helen Evins Campbell and William H. Cline and Melissa J. Evans and J. Lloyd and Anthony W. Peck},
  journal={European Journal of Clinical Pharmacology},
SummaryThe subjective, behavioural and autonomic effects of dexamphetamine 10 mg, 1-benzylpiperazine 100 mg and lactose dummy were compared in a group of 18 former amphetamine addicts. All subjects received the three preparations according to a balanced design under double blind conditions. 1-Benzylpiperazine and dexamphctamine produced indistinguishable subjective effects and both were liked. The effects of both compounds differed significantly from the effects following the dummy preparation… Expand
A comparison of 1-benzylpiperazine and methamphetamine in their acute effects on anxiety-related behavior of hooded rats
Results supported the view that, because of commonalities in their neurochemical effects, benzylpiperazine may have similar abuse and dependence risks to methamphetamine and revealed more similarities than differences. Expand
N-benzylpiperazine has characteristics of a drug of abuse
BZP substituted for cocaine, and drug-naive rats rapidly acquired BZPSelf-administration was maintained by a more restricted range of doses than was cocaine self-Administration, and responding maintained by BzP was sensitive to dopamine antagonism. Expand
Review: Benzylpiperazine: a drug of abuse?
A comprehensive review of the information currently available on BZP is provided and a need for further research into the mechanisms of action, long-term effects and potentially addictive properties is suggested. Expand
Chronic benzylpiperazine (BZP) exposure produces behavioral sensitization and cross-sensitization to methamphetamine (MA).
It is indicated that repeated exposure to BZP results in sensitization and cross-sensitization to MA, which resulted in a potentiated locomotor but not stereotypy response. Expand
Determining the subjective and physiological effects of BZP combined with TFMPP in human males
These physiological and subjective data reflect clear similarities between the effects of BZP/TFMPP and commonly known stimulants such as dexamphetamine and MDMA. Expand
Rewarding properties of 1-benzylpiperazine, a new drug of abuse, in rats.
The results show that 1-benzylpiperazine possesses rewarding properties in the rat, which suggests the compound to be susceptible to human abuse. Expand
Determining the subjective and physiological effects of BZP on human females
Physiological and subjective data reflected a clear similarity between the effects of BZP and those of other commonly known stimulants such as amphetamine and 3,4-methylenedioxymethamphetamine. Expand
The behavioural implications of postnatal exposure to benzylpiperazhie and methamphetamine - a longitudinal doserelated study in male and female rats.
The effect of adolescent exposure to psychostimulant drugs affected anxiety-like behaviours that were observable into middle adulthood, suggesting that the vulnerability to anxiety may be shaped by drug use in adolescence. Expand
Subjective effects in humans following administration of party pill drugs BZP and TFMPP alone and in combination.
The use of piperazine derivatives, colloquially named 'party pills', has been escalating in New Zealand and worldwide since their introduction in the 1990s. Benzylpiperazine (BZP) is often usedExpand
Investigation of the effects of ‘piperazine-containing party pills’ and dexamphetamine on interhemispheric communication using electroencephalography
Interestingly, lateralised hemispheric function was not affected by TFMPP, and the usual directional asymmetry observed in healthy control group was absent following the administration of either BZP, BzP +TFMPP or dexamphetamine. Expand


A comparison of the effects of 1-benzylpiperazine and dexamphetamine on human performance tests
It was concluded that 1-benzylpiperazine has psychomotor stimulant activity similar to dexamphetamine and that this was most reliably detected by using a prolonged signal detection test. Expand
Physiologic, subjective, and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine, and methylphenidate in man
This study suggests that it is unlikely that these central actions in man are a consequence of the release of norepinephrine in the brain, and suggests that these five agents share a common mode of central action. Expand
Actions of a mixture of amphetamine and a barbiturate in man.
The mixture impaired the efficiency of the performance of tasks much less than did the barbiturate drug alone; it produced almost as big a rise in the pulse rate as did amphetamine alone; and it produced reports of feeling "elated" from many more subjects than did either drug separately, though there was no corresponding increase in reports of other feelings and sensations. Expand
Methods for evaluating addiction liability. (A) "Attitude" of opiate addicts toward opiate-like drugs. (B) a short-term "direct" addiction test.
A short, "double-blind," direct addiction, cross-over procedure of 18 to 20 days is satisfactory for developing significant degrees of physical dependence in the case of morphine and codeine-like drugs, but additional studies are necessary to determine its reliability for assessing the degree ofPhysical dependence induced by weak compounds and compounds in the methadone and meperidine series. Expand
Development of Scales Based on Patterns of Drug Effects, Using the Addiction Research Center Inventory (ARCI)
  • C. Haertzen
  • Psychology, Medicine
  • Psychological reports
  • 1966
It was found that the empirical scales show a greater sensitivity to general or non-specific drug effects than pattern scales, and condition-similarity has implications for relating personality to drug effects. Expand
Consistent differences in individual reactions to drugs and dummies.
  • C. Joyce
  • Medicine, Psychology
  • British journal of pharmacology and chemotherapy
  • 1959
The tendency of some individuals to report changes of physical and mental state after taking pharmacologically inert substances has been investigated experimentally and likely reactions of the members of a second class to dummies were predicted from their scores on the same tests. Expand
The Design of Experiments
AbstractREADERS of “Statistical Methods for Research Workers” will welcome Prof. Fisher's new book, which is partly devoted to a development of the logical ideas underlying the earlier volume andExpand
Clinical evaluation of central stimulant effects of fenfluramine and AN.448
  • S. Afr. med. J. (Suppl.)
  • 1971
Detection of dexamphetamine - like activity in man . A comparison of several tests
  • J . Pharm . Chim . ( Paris )
  • 1971
Detection of dexamphetamine-like activity in man
  • A comparison of several tests. J. Pharm. Chim. (Paris)
  • 1971