Comparison of the effects of convulsant and depressant barbiturate stereoisomers on AMPA-type glutamate receptors.

@article{Kamiya1999ComparisonOT,
  title={Comparison of the effects of convulsant and depressant barbiturate stereoisomers on AMPA-type glutamate receptors.},
  author={Yukako Kamiya and Tomio Andoh and Ryo Furuya and Seiji Hattori and Itaru Watanabe and Takuya Sasaki and Hideki Ito and Fukuichiro Okumura},
  journal={Anesthesiology},
  year={1999},
  volume={90 6},
  pages={1704-13}
}
BACKGROUND Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-type glutamate receptors mediate fast excitatory synaptic transmission in the central nervous system. Although barbiturates have been shown to suppress the AMPA receptor-mediated responses, it is unclear whether this effect contributes to the anesthetic action of barbiturates. The authors compared the effects of depressant [R(-)] and convulsant [S(+)] stereoisomers of 1-methyl-5-phenyl-5-propyl barbituric acid (MPPB) on… CONTINUE READING