Comparison of the effects of clonidine and yohimbine on spontaneous pupillary fluctuations in healthy human volunteers

Abstract

Rationale: Spontaneous fluctuations in the size of the pupil in darkness are a recognized index of sleepiness, and these fluctuations can be quantitatively measured using the pupillographic sleepiness test (PST). The central noradrenergic system is believed to play a role in the maintenance of alertness, and there is evidence that α2-adrenoceptor agonists… (More)
DOI: 10.1007/s002130000398

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