Comparison of the effects of botulinum toxin in adult and neonatal rats: neuromuscular blockade and toxicity.

@article{Bambrick1989ComparisonOT,
  title={Comparison of the effects of botulinum toxin in adult and neonatal rats: neuromuscular blockade and toxicity.},
  author={Linda L. Bambrick and Tessa Gordon},
  journal={Canadian journal of physiology and pharmacology},
  year={1989},
  volume={67 8},
  pages={
          879-82
        }
}
  • Linda L. Bambrick, Tessa Gordon
  • Published in
    Canadian journal of…
    1989
  • Medicine
  • A single dose of botulinum toxin (BoTX) was injected subcutaneously to induce neuromuscular blockade in the triceps surae muscles of the hindlimbs of neonatal and adult rats. The efficacy of the toxin in producing complete neuromuscular blockade of the lower limb muscles, assessed by blockade of (a) postural and flexor reflexes and (b) muscle contraction in response to nerve stimulation, was dose dependent at all ages over a BoTX dose range of 10-60 ng/kg. However, BoTX was dramatically more… CONTINUE READING

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