Comparison of the effects of aprotinin and tranexamic acid on blood loss and related variables after cardiopulmonary bypass.
@article{Blauhut1994ComparisonOT, title={Comparison of the effects of aprotinin and tranexamic acid on blood loss and related variables after cardiopulmonary bypass.}, author={Barbara Blauhut and Wolfgang Harringer and Peter Bettelheim and Jan Eva Doran and Peter Sp{\"a}th and Per Lundsgaard-Hansen}, journal={The Journal of thoracic and cardiovascular surgery}, year={1994}, volume={108 6}, pages={ 1083-91 } }
121 Citations
The influence of aprotinin and tranexamic acid on platelet function and postoperative blood loss in cardiac surgery.
- MedicineAnesthesia and analgesia
- 2008
Platelet function measured by whole blood aggregometry is better preserved by aprotinin than tranexamic acid and may be responsible for producing less bleeding within the first 24 h after CPB.
Tranexamic Acid and Aprotinin Reduce Postoperative Bleeding and Transfusions During Primary Coronary Revascularization
- MedicineAnesthesia and analgesia
- 1998
The data show that TA is equivalent to aprotinin for blood conservation in patients at risk of excessive post-CPB bleeding and transfusion therapy, and help to support the use of pharmacologic methods to improve clinically relevant indicators of blood conservation for primary CPB procedures.
Impact of tranexamic acid vs. aprotinin on blood loss and transfusion requirements after cardiopulmonary bypass: a prospective, randomised, double-blind trial
- Medicine
- 2004
TA appears to be a cost-effective alternative to AP in primary CABG patients, and a difference in blood loss between TA and high-dose AP is shown, although statistically significant, it has little clinical relevance.
Postoperative use of aprotinin in cardiac operations: an alternative to its prophylactic use.
- MedicineThe Journal of thoracic and cardiovascular surgery
- 1996
Hemostatic effects of aprotinin, tranexamic acid and ϵ-aminocaproic acid in primary cardiac surgery
- Medicine
- 1999
Aprotinin: an update of its pharmacology and therapeutic use in open heart surgery and coronary artery bypass surgery.
- MedicineDrugs
- 1999
Comparative tolerability and cost-effectiveness data for aprotinin and the lysine analogues are required to more fully assess their individual roles in reducing blood loss and transfusion requirements in patients undergoing CPB during OHS and/or CABG.
Benefits and Risks of Aprotinin Use During Cardiac Surgery
- MedicinePharmacotherapy
- 2008
Clinicians should reserve its use for patients at high risk for postoperative blood loss, and the use of aprotinin could be considered as one component of a blood conservation strategy.
Is e-Aminocaproic Acid as Effective as Aprotinin in Reducing Bleeding With Cardiac Surgery ?
- Medicine
- 1998
e-Aminocaproic acid and aprotinin had no effect on risks of postoperative myocardial infarction or overall mortality, and considerably less-expensive e-aminocapROic acid may be preferred over aProtinin for reducing hemorrhage with cardiac surgery.
Postoperative aprotinin: effect on blood loss and transfusion requirements in cardiac operations.
- MedicineThe Annals of thoracic surgery
- 1996
Is ε-Aminocaproic Acid as Effective as Aprotinin in Reducing Bleeding With Cardiac Surgery? A Meta-Analysis
- Medicine
- 1999
A meta-analysis of 52 randomized clinical trials published between 1985 and 1998 revealed substantial reductions in total blood loss with e-aminocaproic acid and low-dose aprotinin.
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