Comparison of the effects of amikacin and kanamycins A and B on dimyristoylphosphatidylglycerol bilayers. An infrared spectroscopic investigation.

@article{Carrier1997ComparisonOT,
  title={Comparison of the effects of amikacin and kanamycins A and B on dimyristoylphosphatidylglycerol bilayers. An infrared spectroscopic investigation.},
  author={Dyeing Carrier and Nathalie Chartrand and Wadih Y Matar},
  journal={Biochemical pharmacology},
  year={1997},
  volume={53 3},
  pages={401-8}
}
Aminoglycoside antibiotics are very effective against severe Gram-negative infections, but their clinical use is associated with nephrotoxic side-effects. The cascade of events leading to acute renal failure involves an impairment of lysosomal phospholipase activity, which is thought to result from the direct interaction of the drugs with the head group of negative phospholipids. Fourier transform infrared spectroscopy was used to study the effects of three aminoglycosides from the kanamycin… CONTINUE READING