Comparison of the effects of a transient outward potassium channel activator on currents recorded from atrial and ventricular cardiomyocytes.

@article{Calloe2011ComparisonOT,
  title={Comparison of the effects of a transient outward potassium channel activator on currents recorded from atrial and ventricular cardiomyocytes.},
  author={K Calloe and Eyal Nof and Thomas Jespersen and Jos{\'e} M. Di Diego and Natalie Chlus and S. -P. Olesen and Charles Antzelevitch and Jonathan M. Cordeiro},
  journal={Journal of cardiovascular electrophysiology},
  year={2011},
  volume={22 9},
  pages={1057-66}
}
INTRODUCTION NS5806 activates the transient outward potassium current (I(to) ) in canine ventricular cells. We compared the effects of NS5806 on canine atrial versus ventricular tissues and myocytes. METHODS AND RESULTS NS5806 (10 μM) was evaluated in arterially perfused canine right atrial and right ventricular wedge preparations. In ventricular wedges NS5806 (10 μM) accentuated phase 1 in epicardium (Epi), with little effect in endocardium (Endo), resulting in augmented J-waves on the ECG… CONTINUE READING
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Comparison of the effects of the transient outward potassium channel activator NS5806 on canine atrial and ventricular cardiomyocytes

K Calloe, N Chlus, +4 authors JM Cordeiro
Biophys J • 2010

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