Comparison of the effect of left ventricular volume and pressure overload on beta-adrenoceptor density in left heart valvular disease.

@article{Dzimiri1996ComparisonOT,
  title={Comparison of the effect of left ventricular volume and pressure overload on beta-adrenoceptor density in left heart valvular disease.},
  author={Nduna Dzimiri and Azadali Moorji and Manoj Kumar and Nikhil Kumar and Zoltan Halees},
  journal={International journal of cardiology},
  year={1996},
  volume={53 2},
  pages={109-16}
}
The sympathetic responses in left heart valvular disease may depend on the ventricular load conditions. We proposed to evaluate this possibility by comparing the effects of left ventricular pressure (LVP) and volume (LVV) overload on beta-adrenoceptor density and ligand binding affinity in lymphocytes and in the four myocardial chambers in rheumatic heart valvular patients. Receptor activity was determined by radioligand binding using [125I]iodocyanopindolol. In the lymphocytes (n = 45), the… CONTINUE READING