Comparison of the effect of class IA antiarrhythmic drugs on transmembrane potassium currents in rabbit ventricular myocytes.

@article{Iost2003ComparisonOT,
  title={Comparison of the effect of class IA antiarrhythmic drugs on transmembrane potassium currents in rabbit ventricular myocytes.},
  author={Norbert Iost and L{\'a}szl{\'o} Vir{\'a}g and Andr{\'a}s Varr{\'o} and Julius Gy Papp},
  journal={Journal of cardiovascular pharmacology and therapeutics},
  year={2003},
  volume={8 1},
  pages={31-41}
}
BACKGROUND The blockade of cardiac transmembrane potassium channels, which is commonly seen with various antiarrhythmic drugs, plays an important role in their mechanism of action. We studied and compared the less-explored effects of three Class IA antiarrhythmics on the transient outward current (I(to)) and on the inward rectifier (I(kl)), ATP sensitive (I(KATP)), and delayed rectifier (I(K)) potassium currents in rabbit ventricular myocytes. METHODS AND RESULTS Transmembrane currents were… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

Similar Papers

Loading similar papers…