Comparison of the effect of carbon monoxide and of hypoxic hypoxia. II. Hexobarbital metabolism in the isolated, perfused rat liver.

@article{Roth1976ComparisonOT,
  title={Comparison of the effect of carbon monoxide and of hypoxic hypoxia. II. Hexobarbital metabolism in the isolated, perfused rat liver.},
  author={Robert A. Roth and Robert Jay Rubin},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1976},
  volume={199 1},
  pages={
          61-6
        }
}
Rat livers were perfused with a red blood cell-containing perfusion medium. The rate of metabolism of hexobarbital was determined in this system as the recirculating perfusion fluid was made hypoxic by exposure to either CO or lowered oxygen tension. It was found that 7.6% of the total oxygen consumed by the liver was utilized to metabolize hexobarbital regardless of the severity of the hypoxia, which suggests that the liver does not shunt O2 to more preferential pathways as O2 availability… CONTINUE READING