Comparison of the effect of FK506 and cyclosporin A on virus production in H9 cells chronically and newly infected by HIV-1

@article{Briggs1999ComparisonOT,
  title={Comparison of the effect of FK506 and cyclosporin A on virus production in H9 cells chronically and newly infected by HIV-1},
  author={Carlton J Briggs and David E. Ott and Lori V. Coren and Stephen Oroszlan and J{\'o}zsef T{\"o}zs{\'e}r},
  journal={Archives of Virology},
  year={1999},
  volume={144},
  pages={2151-2160}
}
 The presence of FK506-binding protein-12 was demonstrated in virions of HIV-1, although its concentration was lower than that of cyclophilin A. The effect of two inhibitors of the peptidyl-prolyl cis-trans isomerases FK506 and cyclosporin A (CsA) was studied in H9 cells that were chronically infe- cted by HIV-1. Both drugs inhibited virus production in the infected cells in a concentration-dependent manner, by decreasing the number of the producing cells. FK506 did not have an effect on Gag… CONTINUE READING

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Immunophilins and HIV-1 infection

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References

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Effect of cyclosporin A on the replication cycle of HIV-1 derived replication cycle of HIV-1 derived from H9 and Molt-4 producer cells

CJ Briggs, S Tözsér J Oroszlan
J Gen Virol • 1996
View 5 Excerpts
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Cellular proteins in HIV virions.

Reviews in medical virology • 1997

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