Comparison of the dynamics of an engineered insulin monomer and dimer by acid-quenched amide proton exchange. Non-local stabilization of interchain hydrogen bonds by dimerization.

@article{Hua1993ComparisonOT,
  title={Comparison of the dynamics of an engineered insulin monomer and dimer by acid-quenched amide proton exchange. Non-local stabilization of interchain hydrogen bonds by dimerization.},
  author={Qing Xin Hua and Weiping Jia and Bruce H. Frank and M. Angela Weiss},
  journal={Journal of molecular biology},
  year={1993},
  volume={230 2},
  pages={387-94}
}
Dynamic differences between an engineered insulin monomer and dimer are investigated under physiological conditions by an adaptation of the method of acid-quenched amide proton exchange. Although exchange lifetimes of amide protons involved in intrachain hydrogen bonds are similar in the two analogs, dimerization specifically stabilizes two interchain… CONTINUE READING