Comparison of the degradation of type II collagen and proteoglycan in nasal and articular cartilages induced by interleukin-1 and the selective inhibition of type II collagen cleavage by collagenase.

@article{Billinghurst2000ComparisonOT,
  title={Comparison of the degradation of type II collagen and proteoglycan in nasal and articular cartilages induced by interleukin-1 and the selective inhibition of type II collagen cleavage by collagenase.},
  author={R. Clark Billinghurst and William Wu and Mirela Ionescu and Agnes T Reiner and Leif Dahlberg and Jun Chen and Harold E Van Wart and Angelina Poole},
  journal={Arthritis and rheumatism},
  year={2000},
  volume={43 3},
  pages={
          664-72
        }
}
OBJECTIVE To compare interleukin-1alpha (IL-1alpha)-induced degradation of nasal and articular cartilages in terms of proteoglycan loss and type II collagen cleavage, denaturation, and release; to examine the temporal relationship of these changes; and to investigate the effects of an inhibitor of collagenase 2 and collagenase 3 on these catabolic processes. METHODS Discs of mature bovine nasal and articular cartilages were cultured with or without human IL-1alpha (5 ng/ml) with or without… CONTINUE READING
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